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Mutagenicity'Genotoxicity Study for Mutagenicity. Ames-Test OECD 471, EU-Method B13/14; GLP Amount of required substance: 2,57 g Time schedule: 8-12 weeks 2 independent experiments: plate incorporation method and pre-incubation method with and without metabolic activation-lf the test substance is not scuble in demin, H20 or DMSO(Ames specific solvents)...
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Amount of test item: 10 g Time schedule: 4-6 monthsTest system: Human lymphocytes With and without metabolic activation-lf the resut of the first experimert is negative, an additional experiment(without metabdic activation) should be done with a modification(prolonged exposure duration) in the study performance! -Second experment 9.950€ -If...
in vitro Mammalian Cell Micronucleus Test EU-MethodB 49; GLP Amount of required substance 10 g Time schedule: 4 months Test system: Human Lymphocytes First experment 9.500 €-With and without metabolic activation If the result of the first experiment is negative, an additional experiment(withaut metabolic activation) should be performed with...
Mouse Lymphoma Assay in vitro with mammalian cells EU-Method B.17; GLP Amount of required substance: 10-15 g Time schedule: 4 months Celline: L5178Y TK+/- clone(3.7.2C) (mouse lymphocytes) Microtiter plate method: evaluation of small and large coionies First experiment 10.000 € -With and without metabolic activation -lf the result of the...
HPRT Test, Point Mutation in vitro EU-Methode B, 17; GLP Amount of required substance: 10-15 g Time schedule. 4 months Celline V79.4(hamster lung fibroblasts) First experiment 9600 € With and without metabolic activation if the result of the first experiment is negative, an additional experiment(without metabolic activation) should be done...
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